Progressive gut microbiota shifts and functional alterations across aging stages and frailty in mice
Xinwei Jiao, Hongyu Li, Ting Wang, Hongyong Fu, Shiwu Wang, Hong Liu, Lei Wang, Xiuyun Li, Aijun Deng, Zhijie Li
Abstract
, alongside short-chain fatty acid (SCFA) depletion, particularly butanoic acid. Functional predictions revealed elevated immune activity and reduced carbohydrate metabolism, linked to specific microbial taxa. These findings highlight a structured remodeling of the gut microbiota during aging, with frailty representing a distinct dysbiotic state associated with metabolic dysfunction. Modulating gut microbial composition may represent a potential strategy to attenuate frailty and promote healthy aging.
Topics & Concepts
GerontologyGut floraBiologyHealthy agingPhysiologyNeuroscienceMedicineImmunologyGut microbiota and healthDiet and metabolism studiesTryptophan and brain disorders