Global Distribution of <i>mcr</i> Gene Variants in 214K Metagenomic Samples
Hannah-Marie Martiny, Patrick Munk, Christian Brinch, Judit Szarvas, Frank M. Aarestrup, Thomas Nordahl Petersen
Abstract
The ever-growing collection of metagenomic samples available in public data repositories has the potential to reveal new details on the emergence and dissemination of mobilized colistin resistance genes. Our analysis of metagenomes deposited online in the last 10 years shows that the environmental distribution of mcr gene variants depends on sampling source and location, possibly leading to the emergence of new variants, although the contig on which the mcr genes were found remained consistent.
Topics & Concepts
MetagenomicsComputational biologyBiologyGeneDistribution (mathematics)GeneticsMathematicsMathematical analysisBacteriophages and microbial interactionsMolecular Biology Techniques and ApplicationsBacterial Genetics and Biotechnology