Efficacy and complications of ruthenium-106 brachytherapy for uveal melanoma: a systematic review and meta-analysis
Saeed Karimi, Amir Arabi, Zahra Siavashpour, Toktam Shahraki, Iman Ansari
Abstract
PURPOSE: Ru) plaque to treat uveal melanoma. MATERIAL AND METHODS: A literature review was performed based on results from searching PubMed, Embase, Web of Science, Scopus, and Cochrane databases, using the following key words: "choroidal melanoma", "uveal melanoma", "brachytherapy", and "ruthenium-106". We included studies performed on more than 30 patients since 1986, reporting on local control rate, complications rate, mean radiation dose, and mean tumor thickness. The cumulative analysis was performed using Metaprop command of Stata v.16, and meta-regression was conducted based on mean tumor thickness and mean radiation dose to tumor's apex. RESULTS: -value = 0.679). The most commonly reported complications were cataract and radiation-related retinopathy. CONCLUSIONS: Ru in controlling uveal melanomas decreased with the increase in tumor thickness. However, these outcomes should be verified in randomized comparative studies.