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High systemic and tumor-associated IL-8 correlates with reduced clinical benefit of PD-L1 blockade

Kobe Yuen, Lifen Liu, Vinita Gupta, Shravan Madireddi, Shilpa Keerthivasan, Congfen Li, Deepali Rishipathak, Patrick Williams, Edward E. Kadel, Hartmut Koeppen, Ying‐Jiun Chen, Zora Modrušan, Jane L. Grogan, Romain Banchereau, Ning Leng, AnnChristine Thåström, Xiadong Shen, Kenji Hashimoto, Darren Tayama, Michiel S. van der Heijden, Jonathan E. Rosenberg, David F. McDermott, Thomas Powles, Priti S. Hegde, Mahrukh Huseni, Sanjeev Mariathasan

2020Nature Medicine439 citationsDOIOpen Access PDF

Topics & Concepts

AtezolizumabMedicineRenal cell carcinomaOncologyInternal medicineNivolumabImmunotherapyPeripheral blood mononuclear cellImmune systemImmune checkpointMetastatic Urothelial CarcinomaCancerImmunologyBladder cancerUrothelial carcinomaBiochemistryChemistryIn vitroCancer Immunotherapy and BiomarkersBladder and Urothelial Cancer TreatmentsImmune cells in cancer
High systemic and tumor-associated IL-8 correlates with reduced clinical benefit of PD-L1 blockade | Litcius