The DnaK/DnaJ Chaperone System Enables RNA Polymerase-DksA Complex Formation in Salmonella Experiencing Oxidative Stress
Ju-Sim Kim, Lin Liu, Andrés Vázquez‐Torres
Abstract
DksA was discovered 30 years ago in a screen for suppressors that reversed the thermosensitivity of Escherichia coli mutant strains deficient in DnaK/DnaJ, raising the possibility that this chaperone system may control DksA function. Since its serendipitous discovery, DksA has emerged as a key activator of the transcriptional program called the stringent response in Gram-negative bacteria experiencing diverse adverse conditions, including nutritional starvation or oxidative stress.
Topics & Concepts
Chaperone (clinical)Stringent responseBiologyRNA polymeraseSalmonellaEscherichia coliActivator (genetics)BacteriaMutantOxidative stressMicrobiologyPolymeraseCell biologyGeneticsGeneBiochemistryMedicinePathologyBacterial Genetics and BiotechnologyViral gastroenteritis research and epidemiologyEnzyme Structure and Function