High-fat diet promotes colitis-associated tumorigenesis by altering gut microbial butyrate metabolism
Xinyu Shao, Luojie Liu, Yuqing Zhou, Kaiqiang Zhong, Jinrong Gu, Tong Hu, Yizhou Yao, Chunli Zhou, Weichang Chen
Abstract
HFD drives colitis-associated tumorigenesis by inducing gut microbial dysbiosis and inhibiting butyrate metabolism to skew macrophage polarization. Exogenous butyrate is a feasible new treatment strategy for CAC, and has good prospect for clinical application.
Topics & Concepts
ButyrateGut floraDysbiosisProinflammatory cytokineInflammasomeInflammationColitisMacrophage polarizationMetabolismLipopolysaccharideChemistryBiologyMicrobiologyImmunologyEndocrinologyBiochemistryMacrophageIn vitroFermentationGut microbiota and healthEpigenetics and DNA MethylationImmune cells in cancer