A trimodular bacterial enzyme combining hydrolytic activity with oxidative glycosidic bond cleavage efficiently degrades chitin
Sophanit Mekasha, Tina R. Tuveng, Fatemeh Askarian, Swati Choudhary, Claudia Schmidt‐Dannert, Axel Niebisch, Jan Modregger, Gustav Vaaje‐Kolstad, Vincent G. H. Eijsink
Abstract
1381 activity requires close spatial proximity of the LPMO10 and the Chi18 domains. The demonstration of intramolecular synergy between LPMOs and hydrolytic enzymes reported here opens new avenues toward the development of efficient catalysts for biomass conversion.
Topics & Concepts
ChitinGlycosidic bondChitinaseGlycoside hydrolasePolysaccharideEnzymeBiochemistryHydrolysisChemistryBiologyChitosanStudies on Chitinases and ChitosanasesEnzyme Production and CharacterizationBiofuel production and bioconversion