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Profiling the genetic determinants of chromatin accessibility with scalable single-cell CRISPR screens

Noa Liscovitch‐Brauer, Antonino Montalbano, Jiale Deng, Alejandro Méndez‐Mancilla, Hans‐Hermann Wessels, Nicholas Moss, Chia-Yu Kung, Akash Sookdeo, Xinyi Guo, Evan Geller, Suma Jaini, Peter Smibert, Neville E. Sanjana

2021Nature Biotechnology115 citationsDOIOpen Access PDF

Topics & Concepts

ChromatinCRISPRBiologyGeneticsChIA-PETComputational biologyCRISPR interferenceNucleosomeHeterochromatinEpigenomicsGeneCell biologyDNA methylationCas9Gene expressionCRISPR and Genetic EngineeringSingle-cell and spatial transcriptomicsEpigenetics and DNA Methylation
Profiling the genetic determinants of chromatin accessibility with scalable single-cell CRISPR screens | Litcius