Safinamide protects against amyloid β (Aβ)-induced oxidative stress and cellular senescence in M17 neuronal cells
Xunhu Gu, Ge Zhang, Zhengfang Qin, Min Yin, Weiping Chen, Yangbo Zhang, Xu Liu
Abstract
oligomers induction-caused oxidative stress and cellular senescence through SIRT1 signaling. These present results provide meaningful evidence that safinamide may be medically developed for the prevention and therapy of AD.
Topics & Concepts
Oxidative stressCellular senescenceSenescenceCell biologyOxidative damageAmyloid (mycology)ChemistryBiologyBiochemistryPhenotypeGeneInorganic chemistryAlzheimer's disease research and treatmentsTryptophan and brain disordersNeuroscience and Neuropharmacology Research