A fragment integrational approach to GPCR inhibition: Identification of a high affinity small molecule CXCR4 antagonist
Fang Xiong, Qian Meng, Huijun Zhang, Xiao Fang, Lina Huang, Xingquan Zhang, Robert T. Schooley, Aaron Ciechanover, Jing An, Yan Xu, Ziwei Huang
Topics & Concepts
CXCR4 antagonistChemistryCXCR4G protein-coupled receptorChemokine receptorSmall moleculeInternalizationReceptorBiochemistryChemokineCell biologyBiologyChemokine receptors and signalingImmunotherapy and Immune Responsesvaccines and immunoinformatics approaches