Dual targeting of acetylcholinesterase and tau aggregation: Design, synthesis and evaluation of multifunctional deoxyvasicinone analogues for Alzheimer’s disease
Shoaib Manzoor, Moustafa T. Gabr, Bisma Rasool, Kavita Pal, Nasimul Hoda
Topics & Concepts
ChemistryAcetylcholinesteraseAchéIC50NeuroprotectionInhibitory postsynaptic potentialLead compoundTau proteinStereochemistryIn vitroBiochemistryPharmacologyEnzymeAlzheimer's diseaseNeuroscienceDiseasePathologyBiologyMedicineCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery MethodsAlzheimer's disease research and treatments