Medicinal chemistry strategies towards the development of effective SARS-CoV-2 inhibitors
Shenghua Gao, Tianguang Huang, Letian Song, Shujing Xu, Yusen Cheng, Srinivasulu Cherukupalli, Dongwei Kang, Tong Zhao, Lin Sun, Jian Zhang, Peng Zhan, Xinyong Liu
Abstract
Novel therapies are urgently needed to improve global treatment of SARS-CoV-2 infection. Herein, we briefly provide a concise report on the medicinal chemistry strategies towards the development of effective SARS-CoV-2 inhibitors with representative examples in different strategies from the medicinal chemistry perspective.
Topics & Concepts
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)Perspective (graphical)2019-20 coronavirus outbreakChemistryMedicineEngineering ethicsComputer scienceEngineeringVirologyDiseaseInfectious disease (medical specialty)PathologyArtificial intelligenceOutbreakComputational Drug Discovery MethodsSARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research Studies