Somatic mutational landscapes of adherens junctions and their functional consequences in cutaneous melanoma development
Praveen Kumar Korla, Chih-Chieh Chen, Daniel E. Gracilla, Ming‐Tsung Lai, Chih‐Mei Chen, Huan Yuan Chen, Tritium Hwang, Shih‐Yin Chen, Jim Jinn‐Chyuan Sheu
Abstract
Changes in cell-cell communications by somatic mutations in AJ cadherins function as one of mechanisms to trigger melanoma development. Certain mutations in AJs may serve as potential neo-antigens which conversely benefit patients for longer survival times.
Topics & Concepts
Adherens junctionSomatic cellMelanomaBiologyCancer researchCell biologyComputational biologyGeneticsCadherinGeneCellHippo pathway signaling and YAP/TAZWnt/β-catenin signaling in development and cancerCellular Mechanics and Interactions