Kaempferol attenuated cisplatin-induced cardiac injury via inhibiting STING/NF-κB-mediated inflammation.
Yajun Qi, Ying Yin, Jie Zou, Qilu Fang, Xiaohong Yuan, Yingying Cao, Yunfang Cai, Shuang Fu
Abstract
. In H9c2 cells, KPF dramatically reduced cispaltin-induced apoptosis and inflammatory response by modulating STING/NF-κB pathway. In conclusion, these results showed that KPF had great potential in attenuating cisplatin-induced cardiac injury. Besides, greater emphasis should be placed in the future on natural active compounds containing KPF with anti-inflammatory effects for the treatment of these diseases.
Topics & Concepts
CardiotoxicityCisplatinPharmacologyMedicineInflammationApoptosisIn vivoChemotherapyInternal medicineChemistryBiologyBiochemistryBiotechnologyinterferon and immune responsesInflammasome and immune disordersGenomics, phytochemicals, and oxidative stress