Metal-free, visible-light induced enantioselective three-component dicarbofunctionalization and oxytrifluoromethylation of enamines<i>via</i>chiral phosphoric acid catalysis
Hui Liang, Dongsheng Ji, Guo‐Qiang Xu, Yong‐Chun Luo, Haixue Zheng, Peng‐Fei Xu
Abstract
visible-light photocatalysis. Chiral phosphoric acid played multiple roles in the reaction, including controlling the reaction stereoselectivity and promoting the generation of radical intermediates by activating Togni's reagent. Mechanistic studies also suggested the importance of the N-H bond of the enamine and indole for the reactions.
Topics & Concepts
Enantioselective synthesisPhosphoric acidCatalysisComponent (thermodynamics)MetalChemistryCombinatorial chemistryStereochemistryOrganic chemistryPhysicsThermodynamicsRadical Photochemical ReactionsFluorine in Organic ChemistryOxidative Organic Chemistry Reactions