Organophotocatalytic Decarboxylative Allylation of Carboxylic Acids with Allylic Acetates
C. Ju, Xiaoyu Liu, Yanzhe Shi, Yinlei Zhang, Teck‐Peng Loh, Peizhong Xie
Abstract
We developed an acridine-catalyzed, metal- and base-free decarboxylative allylation of carboxylic acids with allylic acetates under mild conditions. The reaction proceeds via a proton-coupled electron transfer (PCET) process, enabling efficient conversion of readily available feedstocks with broad functional group compatibility. This operationally simple and versatile method demonstrates significant potential for synthetic applications, particularly in late-stage modification of bioactive carboxylic acids.
Topics & Concepts
ChemistryAllylic rearrangementOrganic chemistryDecarboxylationCarboxylic acidFunctional groupReaction conditionsCombinatorial chemistryCatalysisGroup (periodic table)Radical Photochemical ReactionsCatalytic C–H Functionalization MethodsOxidative Organic Chemistry Reactions