A HIF-1 signature dominates the attenuation in the human skeletal muscle transcriptional response to high-intensity interval training
Jessica Norrbom, Mia Ydfors, Alen Lovrić, Christopher G. R. Perry, Helene Rundqvist, Eric Rullman
Abstract
This is the first study to address the phenomena of attenuation of the acute exercise response on a global genomic scale with a focus on underlying regulatory machinery and it is, to the best of our knowledge, the first study conducted in humans was exercise-induced regulation of different canonical pathways and transcription factors are contrasted with regards to attenuation after a period with regular exercise training. These results provide evidence for a pathway-specific regulated augmentation of the response to acute exercise over time that tracks with the successive adaptation on the systemic level.
Topics & Concepts
High-intensity interval trainingSkeletal muscleInternal medicineEndocrinologyInterval trainingBiologyGlycolysisMuscle hypertrophyMyostatinTranscriptional regulationGene expressionMedicineGeneMetabolismGeneticsAdipose Tissue and MetabolismGenetics and Physical PerformanceCardiovascular and exercise physiology