Cigarette smoke induces the ROS accumulation and iNOS activation through deactivation of Nrf-2/SIRT3 axis to mediate the human bronchial epithelium ferroptosis
Yawan Zi, Xiaohui Wang, Yafei Zi, Huilin Yu, Yuan Lan, Yuchen Fan, Cheng Ren, Ke Liao, Hong Chen
Topics & Concepts
Reactive oxygen speciesOxidative stressSIRT3PathogenesisRespiratory epitheliumCell biologyChemistryGPX4Mitochondrial ROSCancer researchImmunologyBiologyMedicineEpitheliumBiochemistryPathologySuperoxide dismutaseAcetylationGeneSirtuinGlutathione peroxidaseFerroptosis and cancer prognosisCancer-related molecular mechanisms researchRNA modifications and cancer