Th17 cell-linked mechanisms mediate vascular dysfunction induced by testosterone in a mouse model of gender-affirming hormone therapy
Jeimison Duarte Santos, José Teles de Oliveira Neto, Paula R. Barros, Luis Eduardo Alves Damasceno, Natália Lautherbach, Ana Paula de Assis, Carlos A. A. Silva, Carlos A. Sorgi, Lúcia Helena Faccioli, Ísis do Carmo Kettelhut, Hélio César Salgado, Fernando S. Carneiro, José C. Alves‐Filho, Rita C. Tostes
Abstract
Sex hormone-induced cardiovascular events are important undesirable effects in transgender people under GAHT. Studies addressing the cardiovascular impact of GAHT will certainly contribute to improve healthcare services offered to this population. Our study showing that vascular dysfunction, via Th17 cell-related mechanisms, precedes increased blood pressure induced by testosterone in a GAHT mouse model, reveals potential mechanisms involved in GAHT-related cardiovascular events and may provide new markers/targets for clinical practices in transmasculine people.