Anticancer profile of coumarin 6-based Ir(<scp>iii</scp>) photocatalysts under normoxia and hypoxia by ROS generation and NADH oxidation
Ashish Kumar Yadav, Aarti Upadhyay, Arpan Bera, Rajesh Kushwaha, Arif Ali Mandal, Sagar Acharjee, Amit Kunwar, Samya Banerjee
Abstract
Coumarin 6 appended Ir( iii ) photocatalysts exhibited light activated anticancer effects against cancer cells via mitochondrial depolarization driven apoptosis by inducing type-I (NADH oxidation) and type-II (ROS generation) mechanisms.
Topics & Concepts
CoumarinChemistryReactive oxygen speciesApoptosisDepolarizationHypoxia (environmental)MitochondrionBiochemistryBiophysicsPhotochemistryOxygenBiologyOrganic chemistryNanoplatforms for cancer theranosticsAdvanced Nanomaterials in CatalysisAdvanced biosensing and bioanalysis techniques