Cohort profile: The Singapore Breast Cancer Cohort (SGBCC), a multi-center breast cancer cohort for evaluation of phenotypic risk factors and genetic markers
Peh Joo Ho, Yen Shing Yeoh, Hui Miao, Swee Ho Lim, Ern Yu Tan, Benita Kiat Tee Tan, Veronique Kiak Mien Tan, Su Ming Tan, Wei Sean Yong, Fuh Yong Wong, Preetha Madhukumar, Ching Wan Chan, Philip Tsau Choong Iau, Soo Chin Lee, Thomas Choudary Putti, Shaik Ahmad Buhari, Jin Yee Lee, Geok Hoon Lim, Evan Woo, Zhiyan Yan, Patrick Chan, Juliana Jia Chuan Chen, Sarah Lu, Rebecca Dent, Wai Peng Lee, Chi Wei Mok, Jaime Chin Mui Seah, Xueling Sim, Rob M. van Dam, Kee Seng Chia, Jingmei Li, Mikael Hartman
Abstract
This article aims to provide a detailed description of the Singapore Breast Cancer Cohort (SGBCC), an ongoing multi-ethnic cohort established with the overarching goal to identify genetic markers for breast cancer risk, prognosis and treatment response, as well as to understand the ethnic differences in disease risk and outcome in an Asian setting. The cohort comprises of breast cancer patients aged 21 years and above from six public hospitals which diagnose and treat nearly 76% breast cancer cases in Singapore. Self-reported data on sociodemographic and lifestyle, reproductive risk factors, medical history and family history of breast or ovarian cancer is collected using a structured questionnaire. Clinical data on tumour characteristics, and treatment modalities are obtained through medical record. Bio-specimens (blood or saliva) is collected at recruitment. Follow-up on survival information is done through routine linkage with the Registry of Births and Deaths. As of 31 December 2016, 7,768 subjects have been recruited to the study with 76% subjects contributed bio-specimens. The SGBCC provides a valuable platform which offers a unique, large and rich resource for new research ideas on breast cancer related phenotypic risk factors and genetic markers.