NLRP3 inflammasome activation triggers gasdermin D–independent inflammation
Chun Wang, Tong Yang, Jianqiu Xiao, Canxin Xu, Yael Alippe, Kai Sun, Thirumala‐Devi Kanneganti, Joseph B. Monahan, Yousef Abu‐Amer, Judy Lieberman, Gabriel Mbalaviele
Abstract
mice. Thus, NLRP3 inflammasome activation overwhelms the protection afforded by GSDMD deficiency, rewiring signaling cascades through mechanisms that include GSDME to propagate inflammation.
Topics & Concepts
InflammasomePyroptosisAIM2InflammationCaspase 1SecretionCell biologyProinflammatory cytokinePyrin domainChemistryBiologyBiochemistryImmunologyInflammasome and immune disordersIL-33, ST2, and ILC PathwaysHeme Oxygenase-1 and Carbon Monoxide