What Are the Odds of Finding a COVID-19 Drug from a Lab Repurposing Screen?
A.M. Edwards
Abstract
Massive drug repurposing (or repositioning) campaigns are trying to find potential antiviral treatments for COVID-19. Many involve experimental or virtual screening of libraries of compounds previously proven safe in humans-"old drugs". In 20 years of these efforts in many other diseases, never has a new therapeutic hypothesis derived from screening of old drugs in a lab led to the drug being approved for the new indication.
Topics & Concepts
Drug repositioningRepurposingCoronavirus disease 2019 (COVID-19)DrugSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)2019-20 coronavirus outbreakMedicineDrug discoveryOddsVirtual screeningPharmacologyVirologyBioinformaticsBiologyInternal medicineInfectious disease (medical specialty)OutbreakEcologyDiseaseLogistic regressionPharmacological Receptor Mechanisms and EffectsComputational Drug Discovery MethodsCOVID-19 Clinical Research Studies