KO‐<i>t</i>‐Bu Catalyzed Thiolation of <i>β</i>‐(Hetero)arylethyl Ethers via MeOH Elimination/hydrothiolation
Masanori Shigeno, Yoshiteru Shishido, Kazutoshi Hayashi, Kanako Nozawa‐Kumada, Yoshinori Kondo
Abstract
Abstract Herein, we describe a KO‐ t ‐Bu catalyzed thiolation of β ‐(hetero)arylethyl ethers through MeOH elimination to form (hetero)arylalkenes followed by anti‐Markovnikov hydrothiolation to afford linear thioethers. The system works well with a variety of β ‐(hetero)arylethyl ethers, including electron‐deficient, electron‐neutral, electron‐rich, and branched substrates and a range of aliphatic and aromatic thiols.
Topics & Concepts
ChemistryCatalysisMarkovnikov's ruleCombinatorial chemistryMedicinal chemistryOrganic chemistryStereochemistryRegioselectivitySulfur-Based Synthesis TechniquesChemical Synthesis and ReactionsCyberloafing and Workplace Behavior