Polymerized Luteolin Nanoparticles: Synthesis, Structure Elucidation, and Anti-Inflammatory Activity
Parichat Tawornchat, Thitiporn Pattarakankul, Tanapat Palaga, Varol Intasanta, Supason Wanichwecharungruang
Abstract
C heteronuclear multiple-bond correlation (HMBC) NMR spectroscopic analyses of the oligomers, and a polymerization mechanism is proposed. Unlike luteolin that showed both dose-dependent anti-inflammatory activity and cytotoxicity when tested in lipopolysaccharide-stimulated macrophages, the polyluteolin nanoparticles possess dose-dependent anti-inflammatory activity without causing cell death even at high concentrations.
Topics & Concepts
LuteolinHeteronuclear single quantum coherence spectroscopyHeteronuclear moleculeChemistryPolymerizationBioavailabilityCytotoxicityFlavonoidNuclear chemistryTwo-dimensional nuclear magnetic resonance spectroscopyCarbon-13 NMRNuclear magnetic resonance spectroscopyOrganic chemistryStereochemistryBiochemistryPolymerIn vitroPharmacologyAntioxidantMedicinePhytochemistry and Biological ActivitiesEssential Oils and Antimicrobial ActivityNatural product bioactivities and synthesis