Colchicine attenuates the electrical remodeling of post-operative atrial fibrillation through inhibited expression of immune-related hub genes and stabilization of microtubules
Hangying Ying, Wenpu Guo, Xiaomei Tang, Jun Pan, Pengcheng Yu, Hangping Fan, Xiaochen Wang, Ruhong Jiang, Chenyang Jiang, Ping Liang
Abstract
Acute inflammation promotes α-tubulin degradation, induces electrical remodeling, and both recruits and facilitates the infiltration of circulating myeloid cells. A certain dose of colchicine attenuates electrical remodeling and decreases the recurrence of AF.
Topics & Concepts
InflammationAtrial fibrillationImmune systemLipopolysaccharideMedicinePharmacologyColchicineCancer researchBiologyInternal medicineImmunologyAtrial Fibrillation Management and OutcomesCardiac Fibrosis and RemodelingCell Adhesion Molecules Research