Graphene oxide and its nanocomposites with EDTA or chitosan induce apoptosis in MCF-7 human breast cancer
Ahmed S. Doghish, Gharieb S. El‐Sayyad, Al-Aliaa M. Sallam, Waleed F. Khalil, Waleed M. A. El Rouby
Abstract
. As indicated by the annexin V-FITC apoptosis assay, the total apoptosis highest percentage was in GO-EDTA treatment (30.12%). In addition, the study of cell cycle analysis showed that GO-EDTA arrested the cell cycle primarily in the G0/G1 phase (33.74%). CS- and EDTA-conjugated GO showed an anti-cancer activity through their cytotoxic effect against the MCF-7 breast cancer cell line.
Topics & Concepts
MCF-7GrapheneChitosanNanocompositeHuman breastOxideApoptosisBreast cancerMaterials scienceNanotechnologyCancer researchChemistryNuclear chemistryCancerMedicineInternal medicineMetallurgyBiochemistryGraphene and Nanomaterials ApplicationsNanoparticles: synthesis and applicationsElectrospun Nanofibers in Biomedical Applications