Rise of the human-mouse chimeric brain models
Peng Jiang, Mahabub Alam
Abstract
Human-mouse chimeras offer advantages for studying the pathophysiology of human cells in vivo. Chimeric mouse brains have been created by engrafting human fetal tissue- or pluripotent stem cell-derived progenitor cells into the neonatal mouse brain. This provides new opportunities to understand human brain development and neurological disorders.
Topics & Concepts
Induced pluripotent stem cellNeuroscienceHuman brainChimera (genetics)BiologyProgenitor cellProgenitorStem cellEmbryonic stem cellCell biologyGeneticsGenePluripotent Stem Cells ResearchCongenital heart defects researchNeurogenesis and neuroplasticity mechanisms