DTX3L Enhances Type I Interferon Antiviral Response by Promoting the Ubiquitination and Phosphorylation of TBK1
Jiaqi Huang, Zhengrong Chen, Yunfei Ye, Yu Shao, Peijie Zhu, Xiaoping Li, Yu Ma, Fei Xu, Ji Zhou, Mengyun Wu, Xiu Gao, Yi Yang, Jinping Zhang, Chuangli Hao
Abstract
Our present study evaluated DTX3L as an antiviral molecule by promoting IFN production and establishing an IFN-β-ETS1-DTX3L-TBK1 positive-feedback loop as a novel immunomodulatory step to enhance interferon signaling and inhibit respiratory syncytial virus (RSV) infection. Our finding enriches and complements the biological function of DTX3L and provides a new strategy to protect against lung diseases such as bronchiolitis and pneumonia that develop with RSV.
Topics & Concepts
BiologyUbiquitin ligaseTANK-binding kinase 1UbiquitinInterferonPhosphorylationSignal transductionCell biologyInterferon type IInterferon regulatory factorsTyrosine phosphorylationImmune systemVirologyInnate immune systemImmunologyBiochemistryProtein kinase AMAP kinase kinase kinaseGeneRespiratory viral infections researchinterferon and immune responsesRNA modifications and cancer