Demonstration of age-related blood-brain barrier disruption and cerebromicrovascular rarefaction in mice by longitudinal intravital two-photon microscopy and optical coherence tomography
Ádám Nyúl‐Tóth, Stefano Tarantini, Jordan DelFavero, Feng Yan, Priya Balasubramanian, Andriy Yabluchanskiy, Chetan Ahire, Tamás Kiss, Tamás Csípő, Ágnes Lipécz, Attila E. Farkas, Imola Wilhelm, István A. Krizbai, Qinggong Tang, Anna Csiszár, Zoltán Ungvári
Abstract
Methods are presented for longitudinal detection of age-related increase in blood-brain barrier permeability and microvascular rarefaction in the mouse cerebral cortex by intravital two-photon microscopy and optical coherence tomography.
Topics & Concepts
Intravital microscopyOptical coherence tomographyTwo-photon excitation microscopyMicroscopyRarefaction (ecology)PathologyMaterials scienceOpticsMedicineBiologyMicrocirculationPhysicsRadiologyFluorescenceSpecies diversityEcologyBarrier Structure and Function StudiesNeuroinflammation and Neurodegeneration MechanismsS100 Proteins and Annexins