Atg21 organizes Atg8 lipidation at the contact of the vacuole with the phagophore
Lena Munzel, Piotr Neumann, Florian B. Otto, Roswitha Krick, Janina Metje-Sprink, Benjamin Kroppen, Narain Karedla, Jörg Enderlein, Michael Meinecke, Ralf Ficner, Michael Thumm
Abstract
: FCCS: fluorescence cross correlation spectroscopy; NVJ: nucleus-vacuole junction; PAS: phagophore assembly site; PE: phosphatidylethanolamine; PROPPIN: beta-propeller that binds phosphoinositides; PtdIns3P: phosphatidylinositol- 3-phosphate; VICS: vacuole isolation membrane contact site.
Topics & Concepts
ATG8VacuoleCell biologyBiologyAutophagosomeLipid-anchored proteinCoiled coilPhagosomeAutophagyBiophysicsBiochemistryCytoplasmIntracellularApoptosisCellular transport and secretionRNA Interference and Gene DeliveryWnt/β-catenin signaling in development and cancer