Fluorescent styrylpyrylium probes for the imaging of mitochondria in live cells
Ignacio Muñoz Resta, Federico Lucantoni, Nadezda Apostolova, Francisco Galindo
Abstract
) against Hep3B was found to be in the range of 4.2 μM-11.5 μM, similar to other described anticancer drugs for the same hepatoma cell line. The combined features of a good imaging agent and potential anticancer drug make the family of the studied pyrylium salts good candidates for further theranostic studies. Remarkably, despite the extensive use of pyrylium dyes in several scientific areas (from photocatalysis to optics), there is no precedent description of a styrylpyrylium salt with potential theranostic applications.
Topics & Concepts
ChemistryFluorescenceAcridine orangeBiophysicsColocalizationQuinolinePhototoxicityFluorescence-lifetime imaging microscopyPhotochemistryCombinatorial chemistryBiochemistryIn vitroApoptosisMolecular biologyOrganic chemistryOpticsBiologyPhysicsMolecular Sensors and Ion DetectionLuminescence and Fluorescent MaterialsPhotodynamic Therapy Research Studies