Catch-enrich-release approach for amine-containing natural products
Michelle Jessy Müller, Andrea Dorst, Constanze Paulus, Imran Khan, Simon Sieber
Abstract
Amine-containing natural products are an important class of therapeutic compounds. Herein, we report a chemoselective approach to catch and enrich amine-containing natural products, and release them as underivatized compounds. The strategy exploits the selectivity of the enzyme legumain for the specific release of amine-containing natural products.
Topics & Concepts
Amine gas treatingNatural (archaeology)ChemistryCombinatorial chemistryBiochemical engineeringPolymer scienceOrganic chemistryHistoryEngineeringArchaeologyMicrobial Natural Products and BiosynthesisEnzyme Catalysis and ImmobilizationSynthetic Organic Chemistry Methods