Effect of Melanin Biosynthesis Inhibition on the Antifungal Susceptibility of Chromoblastomycosis Agents
Daiane Heidrich, Danielle Machado Pagani, Alessandra Koehler, Karine de Oliveira Alves, Maria Lúcia Scroferneker
Abstract
Chromoblastomycosis (CBM) is a chronic subcutaneous infection caused by genera of melanized fungi: Fonsecaea , Cladophialophora , Phialophora , Exophiala , and Rhinocladiella . Melanin is a virulence factor known to influence antifungal susceptibility. A specific inhibitor of melanin biosynthesis is tricyclazole.
Topics & Concepts
ItraconazoleChromoblastomycosisPosaconazoleTerbinafineMicrobiologyBiologyAmphotericin BMelaninFluconazolePhaeohyphomycosisPharmacologyAntifungalBiochemistryFungal Infections and StudiesAntifungal resistance and susceptibilityPlant Pathogens and Fungal Diseases