Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy
Jianjun Gao, Lewis Z. Shi, Hao Zhao, Jianfeng Chen, Liangwen Xiong, Qiuming He, Tenghui Chen, Jason Roszik, Chantale Bernatchez, Scott E. Woodman, Pei-Ling Chen, Patrick Hwu, James P. Allison, P. Andrew Futreal, Jennifer A. Wargo, Padmanee Sharma
Topics & Concepts
IpilimumabBiologyCTLA-4MelanomaCancer researchGene knockdownImmune systemImmunologyBlockadeSignal transductionAntibodyImmune checkpointImmunotherapyT cellGeneReceptorGeneticsCancer Immunotherapy and BiomarkersImmunotherapy and Immune ResponsesCAR-T cell therapy research