Discovery and validation of miR-452 as an effective biomarker for acute kidney injury in sepsis
Zhiwen Liu, Danyi Yang, Jingli Gao, Xiaohong Xiang, Xiaoru Hu, Siyao Li, Wenwen Wu, Juan Cai, Chengyuan Tang, Dongshan Zhang, Zheng Dong
Abstract
miR-452 is induced via NF-κB in renal tubular cells in septic AKI. The increase of miR-452, especially that in urine, may be an effective biomarker for early detection of AKI in sepsis patients.
Topics & Concepts
SepsisAcute kidney injuryMedicineUrinary systemBiomarkerCreatinineGastroenterologyInternal medicineUrologyBiologyBiochemistryAcute Kidney Injury ResearchSepsis Diagnosis and TreatmentTraumatic Brain Injury and Neurovascular Disturbances