Nanoscale Metal–Organic Frameworks Stabilize Bacteriochlorins for Type I and Type II Photodynamic Therapy
Taokun Luo, Kaiyuan Ni, August Culbert, Guangxu Lan, Zhe Li, Xiaomin Jiang, Michael Kaufmann, Wenbin Lin
Abstract
-benzoato)bacteriochlorin (TBB) ligands toward oxygen and light via geometrical constraint. Upon 740 nm light irradiation, Zr-TBB efficiently generates various reactive oxygen species, including singlet oxygen, superoxide anion, hydrogen peroxide, and hydroxyl radicals, to afford superb antitumor efficacy on mouse models of breast and colon cancers, with cure rates of 40% and 60%, respectively.
Topics & Concepts
Singlet oxygenChemistryHydrogen peroxidePhotodynamic therapyReactive oxygen speciesSuperoxideRadicalMetal-organic frameworkPhotochemistryNanoscopic scaleOxygenMetalCombinatorial chemistryNanotechnologyOrganic chemistryBiochemistryEnzymeMaterials scienceAdsorptionNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesMetal-Organic Frameworks: Synthesis and Applications