Novel Endochin-Like Quinolones Exhibit Potent <i>In Vitro</i> Activity against Plasmodium knowlesi but Do Not Synergize with Proguanil
Donelly A. van Schalkwyk, Michael K. Riscoe, Sovitj Pou, Rolf W. Winter, Aaron Nilsen, Maëlle Duffey, Robert W. Moon, Colin J. Sutherland
Abstract
Quinolones, such as the antimalarial atovaquone, are inhibitors of the malarial mitochondrial cytochrome bc 1 complex, a target critical to the survival of both liver- and blood-stage parasites, making these drugs useful as both prophylaxis and treatment. Recently, several derivatives of endochin have been optimized to produce novel quinolones that are active in vitro and in animal models. While these quinolones exhibit potent ex vivo activity against Plasmodium falciparum and Plasmodium vivax , their activity against the zoonotic agent Plasmodium knowlesi is unknown.
Topics & Concepts
Plasmodium knowlesiProguanilIn vitroPlasmodium falciparumVirologyBiologyPlasmodium (life cycle)PharmacologyMalariaMedicineGeneticsImmunologyComputer scienceParasite hostingPlasmodium vivaxWorld Wide WebMalaria Research and ControlMosquito-borne diseases and controlResearch on Leishmaniasis Studies