Palladium/copper-cocatalyzed decarbonylative alkynylation of acyl fluorides with alkynylsilanes: synthesis of unsymmetrical diarylethynes
Qiang Chen, Liyan Fu, Yasushi Nishihara
Abstract
Palladium/copper-cocatalyzed decarbonylative alkynylation of acyl fluorides with alkynylsilanes is described. This reaction not only effectively inhibits the formation of undesired homocoupled products by avoiding the addition of a base, but also exhibits a wide substrate scope to provide a general access to diverse unsymmetrical diarylethynes.
Topics & Concepts
AlkynylationChemistryCopperPalladiumCatalysisOrganic chemistryFluorine in Organic ChemistryCatalytic Cross-Coupling ReactionsCatalytic C–H Functionalization Methods