Interplay between MycN and c-Myc regulates radioresistance and cancer stem cell phenotype in neuroblastoma upon glutamine deprivation
Marion Le Grand, Anna Mukha, Jakob Püschel, Emanuele Valli, Alvin Kamili, Orazio Vittorio, Anna Dubrovska, Maria Kavallaris
Abstract
: This study demonstrated that MycN and c-Myc tightly cooperate in regulation of the neuroblastoma CSC phenotypes and radioresistance upon glutamine deprivation. Pharmacologically, strategies targeting glutamine metabolism may prove beneficial in Myc-driven tumors. Consideration of MycN/c-Myc status in selecting neuroblastoma patients for glutamine metabolism treatment will be important to avoid potential radioresistance.
Topics & Concepts
RadioresistanceNeuroblastomaPhenotypeCancer researchCancer stem cellStem cellBiologyCancerGlutamineCellMedicineCell biologyGeneticsCell cultureGeneAmino acidNeuroblastoma Research and TreatmentsCancer, Hypoxia, and MetabolismCancer therapeutics and mechanisms