Type I macrophage activator photosensitizer against hypoxic tumors
Guang Yang, Song‐Bo Lu, Chong Li, Feng Chen, Jen‐Shyang Ni, Menglei Zha, Yaxi Li, Ji Gao, Tianyi Kang, Chao Liu, Kai Li
Abstract
anti-tumor experiments revealed that the TPA-DCR NPs could further trigger tumor immune response by re-educating tumor-associated macrophages toward M1 phenotype and promoting T cell infiltration. Overall, this work demonstrates the design of type I organic photosensitizers and mechanistic investigation of their superior anti-tumor efficacy. The results will benefit the exploration of advanced strategies to regulate the tumor microenvironment for effective photodynamic immunotherapy against hypoxic tumors.
Topics & Concepts
PhotosensitizerActivator (genetics)Cancer researchChemistryMacrophageMedicinePhotochemistryBiochemistryIn vitroReceptorNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesCancer, Hypoxia, and Metabolism