Age-related decline in bone mineral transport and bone matrix proteins in osteoblasts from stromal stem cells
Irina L. Tourkova, Quitterie C. Larrouture, Kelechi M. Onwuka, Silvia Liu, Jianhua Luo, Paul H. Schlesinger, Harry C. Blair
Abstract
This work for the first time showed that specific enzymes in bone mineral transport, and matrix synthesis proteins, in the epithelial-like bone-forming cell layer are downregulated with aging. Results were compared using cells extracted from long bones of young and old mice, or in essentially uniform osteoblasts differentiated from stromal stem cells in vitro. The age effect showed memory in the stromal stem cells, a remarkable finding.
Topics & Concepts
Stromal cellStem cellCell biologyMatrix (chemical analysis)Bone matrixIn vitroBone mineralChemistryBiologyEndocrinologyAnatomyBiochemistryCancer researchOsteoporosisChromatographyCartilageAlkaline Phosphatase Research StudiesVitamin D Research StudiesFolate and B Vitamins Research