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YAP/TAZ drives cell proliferation and tumour growth via a polyamine–eIF5A hypusination–LSD1 axis

Hongde Li, Bo-Kuan Wu, Mohammed Kanchwala, Jing Cai, Li Wang, Chao Xing, Yonggang Zheng, Duojia Pan

2022Nature Cell Biology101 citationsDOIOpen Access PDF

Topics & Concepts

PolyamineOrnithine decarboxylaseCell biologyCell growthBiologyCarcinogenesisDownregulation and upregulationHippo signaling pathwayTranscription factorEffectorCancer researchChemistryBiochemistryGeneEnzymePolyamine Metabolism and ApplicationsEpigenetics and DNA MethylationCancer-related gene regulation
YAP/TAZ drives cell proliferation and tumour growth via a polyamine–eIF5A hypusination–LSD1 axis | Litcius