Macrophage angiotensin AT<sub>2</sub> receptor activation is protective against early phases of LPS-induced acute kidney injury
Naureen Fatima, Riyasat Ali, Tahmid Faisal, Kalyani Kulkarni, Sanket Patel, Tahir Hussain
Abstract
Endotoxin such as lipopolysaccharide (LPS) induces acute kidney injury (AKI), which is a risk factor for and often leads to chronic kidney diseases. The present study revealed that bone marrow-derived macrophage activation of the angiotensin II type 2 receptor (AT 2 R) contributes to the anti-inflammation and partial renoprotection against early stages of LPS-induced AKI. Since AT 2 R is an emerging anti-inflammatory and organ-protective target, this study advances our understanding of AT 2 R’s anti-inflammatory mechanisms associated with renoprotection.
Topics & Concepts
Acute kidney injuryMacrophageKidneyReceptorMedicineAngiotensin IIInternal medicinePharmacologyChemistryBiochemistryIn vitroAcute Kidney Injury ResearchElectrolyte and hormonal disordersTrauma, Hemostasis, Coagulopathy, Resuscitation