Electrochemical biosensing of sperm protein 17 in clinical samples using a hydrothermally synthesized MoS <sub>2</sub> @rGO@MWCNTs ternary system without prior pre-treatment
Amit K. Yadav, Damini Verma, Pratima R. Solanki
Abstract
. The mechanism behind the sensing is attributed to charge transfer-induced shifts in the Fermi level, causing band bending at the interface between the nanosystem and the target molecule, leading to enhanced sensitivity. The theoretical analysis correlates these Fermi energy shifts with device sensitivity, particularly with antibody immobilization. The immunosensor was successfully used to detect Sp17 in human serum samples, showing good accuracy, reproducibility, and selectivity. It also correlated with a commercial enzyme-linked immunosorbent assay (ELISA), suggesting its potential for clinical diagnostics, particularly for ovarian and other Sp17-related cancers.
Topics & Concepts
Materials scienceTernary operationElectrochemistryNanotechnologyElectrodeBiosensorCarbon nanotubeChemical engineeringChemistryComputer sciencePhysical chemistryProgramming languageEngineeringAdvanced biosensing and bioanalysis techniquesQuantum Dots Synthesis And PropertiesNanowire Synthesis and Applications