Hypusination Orchestrates the Antimicrobial Response of Macrophages
Alain P. Gobert, Jordan L. Finley, Yvonne L. Latour, Mohammad Asim, Thaddeus M. Smith, Thomas G. Verriere, Daniel P. Barry, Margaret M. Allaman, Alberto G. Delagado, Kristie L. Rose, M. Wade Calcutt, Kevin L. Schey, Johanna C. Sierra, M. Blanca Piazuelo, Raghavendra G. Mirmira, Keith T. Wilson
Abstract
in macrophages and increased bacterial burden and inflammation. Thus, regulation of translation through hypusination is a critical hallmark of the defense of eukaryotic hosts against pathogenic bacteria.
Topics & Concepts
DHPSBiologyEffectorMicrobiologyInnate immune systemAutophagyTranslation (biology)Cell biologyImmune systemBiochemistryMessenger RNAGeneImmunologyPlasmodium falciparumApoptosisMalariaPolyamine Metabolism and ApplicationsMast cells and histamineCannabis and Cannabinoid Research