Genetic Inhibition of<i>PCSK9</i>and Liver Function
Antoine Rimbert, Sarra Smati, Wieneke Dijk, Cédric Le May, Bertrand Cariou
Abstract
This study investigates associations of the lifelong genetic inhibition of PCSK9 with plasma liver enzymes and nonalcoholic fatty liver disease by using the loss-of-function variant PCSK9-p.Arg46Leu as a genetic instrument.
Topics & Concepts
PCSK9MedicineNonalcoholic fatty liver diseaseLiver enzymeFatty liverLiver functionInternal medicineBioinformaticsDiseaseCholesterolLDL receptorBiologyLipoproteinLipoproteins and Cardiovascular HealthComputational Drug Discovery MethodsProtein Kinase Regulation and GTPase Signaling