A palladium catalyzed asymmetric desymmetrization approach to enantioenriched 1,3-disubstituted isoindolines
Dattatraya H. Dethe, Vimlesh Kumar, Manmohan Shukla
Abstract
-1,3-disubstituted isoindoline derivatives. The use of a readily accessible mono-N-protected amino acid as a chiral ligand improves the efficiency and enantioselectivity of the catalytic transformation. The developed method provides access to both enantiomers of a product using either d or l-phenylalanine derivative as a chiral ligand facilitating the synthesis of both optically active 1,3-disubstituted isoindoline derivatives.
Topics & Concepts
IsoindolineDesymmetrizationEnantioselective synthesisChemistryPalladiumCatalysisEnantiomerLigand (biochemistry)Combinatorial chemistryStereochemistryAnnulationDerivative (finance)Organic chemistryEconomicsReceptorFinancial economicsBiochemistryCatalytic C–H Functionalization MethodsSynthesis and pharmacology of benzodiazepine derivativesOxidative Organic Chemistry Reactions