Synthesis, biological evaluation and docking studies of methylene bearing cyanopyrimidine derivatives possessing a hydrazone moiety as potent Lysine specific demethylase-1 (LSD1) inhibitors: A promising anticancer agents
Sharba Tasneem, Khursheed Ahmad Sheikh, Md. Naematullah, Mohammad Mumtaz Alam, Farah Khan, Manika Garg, Mohd Amir, Mymoona Akhter, Shaista Amin, Anzarul Haque, Mohammad Shaquiquzzaman
Topics & Concepts
ChemistryHydrazoneDemethylaseDocking (animal)MoietyLead compoundStereochemistryIn vitroCytochrome P450BiochemistryMetabolismEpigeneticsNursingMedicineGeneSynthesis and biological activityGenomics, phytochemicals, and oxidative stressHistone Deacetylase Inhibitors Research