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Considerations and perspectives on phage therapy from the transatlantic taskforce on antimicrobial resistance

Kyung D. Moon, Carmen Coxon, Christine Årdal, Radu Botgros, Sarah Djebara, Laura Durno, Cara R. Fiore, J Perrin, Dennis M. Dixon, Marco Cavaleri

2025Nature Communications21 citationsDOIOpen Access PDF

Abstract

Amid rising antimicrobial resistance and limited antibiotic innovation, bacteriophages are gaining attention as potential therapeutics across human health, animal, and food sectors. Despite historical use, their clinical application in humans remains constrained by scientific, industrial, and regulatory challenges. To address these issues, the Transatlantic Task Force on Antimicrobial Resistance (TATFAR) convened sessions with experts from member parties. This perspective synthesizes insights from the TATFAR group, highlighting regulatory differences, research gaps, and opportunities for international collaborations to advance bacteriophage therapy.

Topics & Concepts

Antibiotic resistancePhage therapyTask forceAntimicrobialMedicineBacteriophageTask (project management)Resistance (ecology)Perspective (graphical)Intensive care medicineMEDLINEClinical microbiologyDrug approvalBiotechnologyDrug resistanceAntibioticsVirologyEngineering ethicsAntimicrobial stewardshipSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)MicrobiologyPrecision medicineBiologyAntibiotic therapyPolitical scienceLicensureBacteriophages and microbial interactionsRNA and protein synthesis mechanismsCancer Research and Treatments
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